Gene information
Official symbol SIRT3
Official full name sirtuin 3
Gene type protein-coding gene
Chromosome11p15.5
Alias symbolSIR2L3
Gene familySirtuins
Resources
Entrez Gene 23410
HGNC HGNC:14931
Ensembl ENSG00000142082
Vega OTTHUMG00000119074
UCSC uc001lok.5
GO terms: 21 records
GO Description Category LogP Number of genes Detail
GO:0004407 histone deacetylase activity GO Molecular Functions -5.51573627 5 More
GO:0006471 protein ADP-ribosylation GO Biological Processes -3.56106200 4 More
GO:0006476 protein deacetylation GO Biological Processes -5.10714110 7 More
GO:0016570 histone modification GO Biological Processes -1.66018959 10 More
GO:0016575 histone deacetylation GO Biological Processes -4.19317336 6 More
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO Molecular Functions -7.39079179 12 More
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO Molecular Functions -6.05306731 14 More
GO:0017136 NAD-dependent histone deacetylase activity GO Molecular Functions -7.01671945 4 More
GO:0019213 deacetylase activity GO Molecular Functions -6.62830099 7 More
GO:0019216 regulation of lipid metabolic process GO Biological Processes -24.8423986 38 More
GO:0033558 protein lysine deacetylase activity GO Molecular Functions -6.90547690 6 More
GO:0034979 NAD-dependent protein deacetylase activity GO Molecular Functions -8.868615 5 More
GO:0034983 peptidyl-lysine deacetylation GO Biological Processes -5.88286021 4 More
GO:0035601 protein deacylation GO Biological Processes -4.62709399 7 More
GO:0045834 positive regulation of lipid metabolic process GO Biological Processes -24.1838255 28 More
GO:0046889 positive regulation of lipid biosynthetic process GO Biological Processes -14.1380112 16 More
GO:0046890 regulation of lipid biosynthetic process GO Biological Processes -16.6841590 23 More
GO:0051287 NAD binding GO Molecular Functions -4.51461289 6 More
GO:0051341 regulation of oxidoreductase activity GO Biological Processes -18.1249013 32 More
GO:0070403 NAD+ binding GO Molecular Functions -6.04894404 5 More
GO:0098732 macromolecule deacylation GO Biological Processes -4.47323224 7 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa00760 Nicotinate and nicotinamide metabolism KEGG Pathway -6.71495876 7 More
Drug-Gene interaction
view
Related drugs: 3 records
Drug name Interaction type Source PMID View
chembl1501622 DTC 22835719 view
niacinamide DTC 22835719 view
suramin DTC 22835719 view
Related studies: 3 records
Molecular factor Omics type Application Objective MI type Reference
NC_000011.10:g.236370C>G genomics myocardial infarction[diagnosis] myocardial infarction Yin X et al. PLoS One. 2016
NC_000011.10:g.236473C>T genomics myocardial infarction[diagnosis] myocardial infarction Yin X et al. PLoS One. 2016
NC_000011.10:g.236380_236381insCCCGCGGCGCCCCA genomics myocardial infarction[diagnosis] myocardial infarction Yin X et al. PLoS One. 2016
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